Angiopoietin-1

BE0010681ProteinHumansANGPT1

Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. It is acted on by 1 drug in DrugBank.

Gene name
ANGPT1
UniProtKB entry
Q15389Swiss-Prot
Cellular location
Secreted
Residues / weight
498 residues · 57,513 Da
Also known as
ANG-1 · KIAA0003

Resolves to

Protein
UniProtQ15389UniProt nameANGP1_HUMAN
Gene
HGNCHGNC:484NCBI Gene284GeneCardsANGPT1
Pharmacology
KEGGhsa:284
Structure
PDB4EPUPDB4JYOPDB4K0V
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Angiopoietin-1, and which indications are they being tested in?

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