T-cell immunoreceptor with Ig and ITIM domains

BE0010742ProteinHumansTIGIT

Inhibitory receptor that plays a role in the modulation of immune responses. It is acted on by 8 drugs in DrugBank.

Gene name
TIGIT
UniProtKB entry
Q495A1Swiss-Prot
Cellular location
Cell membrane
Residues / weight
244 residues · 26,319 Da
Also known as
V-set and immunoglobulin domain-containing protein 9 · V-set and transmembrane domain-containing protein 3 · VSIG9 · VSTM3

Resolves to

Protein
UniProtQ495A1UniProt nameTIGIT_HUMAN
Gene
HGNCHGNC:26838NCBI Gene201633GeneCardsTIGIT
Pharmacology
KEGGhsa:201633
Structure
PDB3Q0HPDB3RQ3PDB3UCR
Drugs

What you can answer from here — as of October 31, 2023

8DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which compounds in development act on T-cell immunoreceptor with Ig and ITIM domains, and which indications are they being tested in?

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