DNA polymerase theta

BE0010760ProteinHumansPOLQ

Low-fidelity DNA polymerase with a putative helicase activity that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery required to repair double-strand breaks in DNA during mitosis (PubMed:14576298, PubMed:18503084, PubMed:24648516, PubMed:25642963, PubMed:25643323, PubMed:25775267, PubMed:26636256,... It is acted on by 1 drug in DrugBank.

Gene name
POLQ
UniProtKB entry
O75417Swiss-Prot
Cellular location
Nucleus
Residues / weight
2,590 residues · 289,617 Da
Also known as
DNA polymerase eta · POLH

Resolves to

Protein
UniProtO75417UniProt nameDPOLQ_HUMAN
Gene
HGNCHGNC:9186NCBI Gene10721GeneCardsPOLQ
Pharmacology
IUPHAR/GtoPdb3230KEGGhsa:10721
Structure
PDB4X0PPDB4X0QPDB5A9F
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
13GO termsFunction, process and component, as structured annotations
Sign in
6Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
1+ReferenceStructured and connected to the statements they support
Sign in

Which approved drugs act on DNA polymerase theta, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In