Beta-klotho

BE0010795ProteinHumansKLB

Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. It is acted on by 4 drugs in DrugBank.

Gene name
KLB
UniProtKB entry
Q86Z14Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,044 residues · 119,807 Da
Also known as
BetaKlotho · BKL · Klotho beta-like protein

Resolves to

Protein
UniProtQ86Z14UniProt nameKLOTB_HUMAN
Gene
HGNCHGNC:15527NCBI Gene152831GeneCardsKLB
Pharmacology
KEGGhsa:152831
Structure
PDB5VAKPDB5VANPDB5VAQ
Drugs

What you can answer from here — as of October 31, 2023

4DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Beta-klotho, and which indications are they being tested in?

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