V-type immunoglobulin domain-containing suppressor of T-cell activation

BE0010797ProteinHumansVSIR

Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). It is acted on by 1 drug in DrugBank.

Gene name
VSIR
UniProtKB entry
Q9H7M9Swiss-Prot
Cellular location
Cell membrane
Residues / weight
311 residues · 33,908 Da
Also known as
C10orf54 · Platelet receptor Gi24 · Sisp-1 · SISP1 · Stress-induced secreted protein-1

Resolves to

Protein
UniProtQ9H7M9UniProt nameVISTA_HUMAN
Gene
HGNCHGNC:30085NCBI Gene64115GeneCardsVSIR
Pharmacology
IUPHAR/GtoPdb2956KEGGhsa:64115
Structure
PDB6MVLPDB6OILPDB6U6V
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on V-type immunoglobulin domain-containing suppressor of T-cell activation, and which indications are they being tested in?

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