Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

BE0010803ProteinHumansINPP5D

Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10764818, PubMed:8723348, PubMed:8769125). It is acted on by 1 drug in DrugBank.

Gene name
INPP5D
UniProtKB entry
Q92835Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,189 residues · 133,291 Da
Also known as
3.1.3.86 · hp51CN · Inositol polyphosphate-5-phosphatase D · Inositol polyphosphate-5-phosphatase of 145 kDa · p150Ship

Resolves to

Protein
UniProtQ92835UniProt nameSHIP1_HUMAN
Gene
HGNCHGNC:6079NCBI Gene3635GeneCardsINPP5D
Pharmacology
KEGGhsa:3635
Structure
PDB2YSXPDB5RW2PDB5RW3
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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4GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, and which indications are they being tested in?

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