Leucine-rich repeat-containing G protein-coupled receptor 5

BE0010835ProteinHumansLGR5

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. It is acted on by 1 drug in DrugBank.

Gene name
LGR5
UniProtKB entry
O75473Swiss-Prot
Cellular location
Cell membrane
Residues / weight
907 residues · 99,997 Da
Also known as
G protein-coupled receptor 49 · G protein-coupled receptor 67 · G protein-coupled receptor HG38 · GPR49 · GPR67

Resolves to

Protein
UniProtO75473UniProt nameLGR5_HUMAN
Gene
HGNCHGNC:4504NCBI Gene8549GeneCardsLGR5
Pharmacology
IUPHAR/GtoPdb148KEGGhsa:8549
Structure
PDB4BSRPDB4BSSPDB4BST
Drugs

What you can answer from here — as of June 19, 2026

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Leucine-rich repeat-containing G protein-coupled receptor 5, and which indications are they being tested in?

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