DNA repair protein RAD50

BE0010839ProteinHumansRAD50

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:15064416, PubMed:21757780, PubMed:27889449, PubMed:28134932, PubMed:28867292, PubMed:9590181, PubMed:9651580, PubMed:9705271). It is acted on by 1 drug in DrugBank.

Gene name
RAD50
UniProtKB entry
Q92878Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,312 residues · 153,891 Da
Also known as
3.6.-.- · hRAD50

Resolves to

Protein
UniProtQ92878UniProt nameRAD50_HUMAN
Gene
HGNCHGNC:9816NCBI Gene10111GeneCardsRAD50
Pharmacology
KEGGhsa:10111
Structure
PDB5GOXPDB9Q9HPDB9Q9I
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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33GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on DNA repair protein RAD50, and which indications are they being tested in?

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