Reticulon-4

BE0010844ProteinHumansRTN4

Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). It is acted on by 2 drugs in DrugBank.

Gene name
RTN4
UniProtKB entry
Q9NQC3Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
1,192 residues · 129,930 Da
Also known as
Foocen · KIAA0886 · Neurite outgrowth inhibitor · Neuroendocrine-specific protein · Neuroendocrine-specific protein C homolog

Resolves to

Protein
UniProtQ9NQC3UniProt nameRTN4_HUMAN
Gene
HGNCHGNC:14085NCBI Gene57142GeneCardsRTN4
Pharmacology
IUPHAR/GtoPdb2838KEGGhsa:57142
Structure
PDB2G31PDB2JV5
Drugs

What you can answer from here — as of October 31, 2023

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Reticulon-4, and which indications are they being tested in?

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