Cell division cycle 7-related protein kinase
Details
- Name
- Cell division cycle 7-related protein kinase
- Kind
- protein
- Synonyms
- 2.7.11.1
- CDC7-related kinase
- CDC7L1
- HsCdc7
- huCdc7
- Gene Name
- CDC7
- UniProtKB Entry
- O00311Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0053986|Cell division cycle 7-related protein kinase MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKI EDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGV KYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKP SNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSG PVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISH ESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVC SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD LTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQ GHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPD EAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
- Number of residues
- 574
- Molecular Weight
- 63887.645
- Theoretical pI
- Not Available
- GO Classification
- Not Available
- General Function
- Kinase involved in initiation of DNA replication. Phosphorylates critical substrates that regulate the G1/S phase transition and initiation of DNA replication, such as MCM proteins and CLASPIN
- Specific Function
- Atp binding
- Pfam Domain Function
- Pkinase (PF00069)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0053987|Cell division cycle 7-related protein kinase (CDC7) ATGGAGGCGTCTTTGGGGATTCAGATGGATGAGCCAATGGCTTTTTCTCCCCAGCGTGAC CGGTTTCAGGCTGAAGGCTCTTTAAAAAAAAACGAGCAGAATTTTAAACTTGCAGGTGTT AAAAAAGATATTGAGAAGCTTTATGAAGCTGTACCACAGCTTAGTAATGTGTTTAAGATT GAGGACAAAATTGGAGAAGGCACTTTCAGCTCTGTTTATTTGGCCACAGCACAGTTACAA GTAGGACCTGAAGAGAAAATTGCTCTAAAACACTTGATTCCAACAAGTCATCCTATAAGA ATTGCAGCTGAACTTCAGTGCCTAACAGTGGCTGGGGGGCAAGATAATGTCATGGGAGTT AAATACTGCTTTAGGAAGAATGATCATGTAGTTATTGCTATGCCATATCTGGAGCATGAG TCGTTTTTGGACATTCTGAATTCTCTTTCCTTTCAAGAAGTACGGGAATATATGCTTAAT CTGTTCAAAGCTTTGAAACGCATTCATCAGTTTGGTATTGTTCACCGTGATGTTAAGCCC AGCAATTTTTTATATAATAGGCGCCTGAAAAAGTATGCCTTGGTAGACTTTGGTTTGGCC CAAGGAACCCATGATACGAAAATAGAGCTTCTTAAATTTGTCCAGTCTGAAGCTCAGCAG GAAAGGTGTTCACAAAACAAATCCCACATAATCACAGGAAACAAGATTCCACTGAGTGGC CCAGTACCTAAGGAGCTGGATCAGCAGTCCACCACAAAAGCTTCTGTTAAAAGACCCTAC ACAAATGCACAAATTCAGATTAAACAAGGAAAAGACGGAAAGGAGGGATCTGTAGGCCTT TCTGTCCAGCGCTCTGTTTTTGGAGAAAGAAATTTCAATATACACAGCTCCATTTCACAT GAGAGCCCTGCAGTGAAACTCATGAAGCAGTCAAAGACTGTGGATGTACTGTCTAGAAAG TTAGCAACAAAAAAGAAGGCTATTTCTACAAAAGTTATGAATAGTGCTGTGATGAGGAAA ACTGCCAGTTCTTGCCCAGCTAGCCTGACCTGTGACTGCTATGCAACAGATAAAGTTTGT AGTATTTGCCTTTCAAGGCGTCAGCAGGTTGCCCCTAGGGCAGGTACACCAGGATTCAGA GCACCAGAGGTCTTGACAAAGTGCCCCAATCAAACTACAGCAATTGACATGTGGTCTGCA GGTGTCATATTTCTTTCTTTGCTTAGTGGACGATATCCATTTTATAAAGCAAGTGATGAT TTAACTGCTTTGGCCCAAATTATGACAATTAGGGGATCCAGAGAAACTATCCAAGCTGCT AAAACTTTTGGGAAATCAATATTATGTAGCAAAGAAGTTCCAGCACAAGACTTGAGAAAA CTCTGTGAGAGACTCAGGGGTATGGATTCTAGCACTCCCAAGTTAACAAGTGATATACAA GGGCATGCTTCTCATCAACCAGCTATTTCAGAGAAGACTGACCATAAAGCTTCTTGCCTC GTTCAAACACCTCCAGGACAATACTCAGGGAATTCATTTAAAAAGGGGGATAGTAATAGC TGTGAGCATTGTTTTGATGAGTATAATACCAATTTAGAAGGCTGGAATGAGGTACCTGAT GAAGCTTATGACCTGCTTGATAAACTTCTAGATCTAAATCCAGCTTCAAGAATAACAGCA GAAGAAGCTTTGTTGCATCCATTTTTTAAAGATATGAGCTTGTGA
- Chromosome Location
- 1
- Locus
- 1p22.1
- External Identifiers
Resource Link UniProtKB ID O00311 UniProtKB Entry Name CDC7_HUMAN GeneCard ID CDC7 HGNC ID HGNC:1745 PDB ID(s) 4F99, 4F9A, 4F9B, 4F9C, 5UWQ, 5UWR, 6YA6, 6YA7, 6YA8 KEGG ID hsa:8317 IUPHAR/Guide To Pharmacology ID 1960 NCBI Gene ID 8317 - General References
- Not Available
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one experimental yes target inhibitor Details PHA-767491 investigational yes target modulator Details Simurosertib investigational yes target inhibitor Details BMS-863233 investigational yes target modulator Details