Mannan-binding lectin serine protease 1

BE0010872ProteinHumansMASP1

Precursor of a serum protease that activates the complement pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. It is acted on by 1 drug in DrugBank.

Gene name
MASP1
UniProtKB entry
P48740Swiss-Prot
Cellular location
Secreted
Residues / weight
699 residues · 79,246 Da
Also known as
3.4.21.- · Complement-activating component of Ra-reactive factor · CRARF · CRARF1 · Mannose-binding lectin-associated serine protease 1

Resolves to

Protein
UniProtP48740UniProt nameMASP1_HUMAN
Gene
HGNCHGNC:6901NCBI Gene5648GeneCardsMASP1
Pharmacology
KEGGhsa:5648
Structure
PDB3DEMPDB3GOVPDB4AQB
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Mannan-binding lectin serine protease 1, and which indications are they being tested in?

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