Prelamin-A/C

BE0010877ProteinHumansLMNA

Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:10080180, PubMed:10580070,... It is acted on by 1 drug in DrugBank.

Gene name
LMNA
UniProtKB entry
P02545Swiss-Prot
Cellular location
Nucleus lamina
Residues / weight
664 residues · 74,139 Da
Also known as
LMN1

Resolves to

Protein
UniProtP02545UniProt nameLMNA_HUMAN
Gene
HGNCHGNC:6636NCBI Gene4000GeneCardsLMNA
Pharmacology
KEGGhsa:4000
Structure
PDB1IFRPDB1IVTPDB1X8Y
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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6Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Prelamin-A/C, and which indications are they being tested in?

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