Lysosomal acid lipase/cholesteryl ester hydrolase

BE0010879ProteinHumansLIPA

Catalyzes the deacylation of cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol (PubMed:15269241, PubMed:1718995, PubMed:7204383, PubMed:8112342, PubMed:9633819). It is acted on by 2 drugs in DrugBank.

Gene name
LIPA
UniProtKB entry
P38571Swiss-Prot
Cellular location
Lysosome
Residues / weight
399 residues · 45,419 Da
Also known as
3.1.1.13 · Acid cholesteryl ester hydrolase · Cholesteryl esterase · Diacylglycerol lipase · LAL

Resolves to

Protein
UniProtP38571UniProt nameLICH_HUMAN
Gene
HGNCHGNC:6617NCBI Gene3988GeneCardsLIPA
Pharmacology
KEGGhsa:3988
Structure
PDB6V7N
Drugs

What you can answer from here — as of October 31, 2023

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Lysosomal acid lipase/cholesteryl ester hydrolase, how selective are they, and which programs against it are still in active trials?

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