DNA polymerase subunit gamma-2

BE0010885ProteinHumansPOLG2

Accessory subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). It is acted on by 1 drug in DrugBank.

Gene name
POLG2
UniProtKB entry
Q9UHN1Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
485 residues · 54,911 Da
Also known as
DNA polymerase gamma accessory 55 kDa subunit · Mitochondrial DNA polymerase accessory subunit · MTPOLB · p55 · PolG-beta

Resolves to

Protein
UniProtQ9UHN1UniProt nameDPOG2_HUMAN
Gene
HGNCHGNC:9180NCBI Gene11232GeneCardsPOLG2
Pharmacology
KEGGhsa:11232
Structure
PDB2G4CPDB3IKLPDB3IKM
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on DNA polymerase subunit gamma-2, how selective are they, and which programs against it are still in active trials?

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