Glycerol-3-phosphate dehydrogenase, mitochondrial

BE0010904ProteinHumansGPD2

Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device. It is acted on by 1 drug in DrugBank.

Gene name
GPD2
UniProtKB entry
P43304Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
727 residues · 80,852 Da
Also known as
1.1.5.3 · GPD-M · GPDH-M · mGDH · mitochondrial glycerophosphate dehydrogenase gene

Resolves to

Protein
UniProtP43304UniProt nameGPDM_HUMAN
Gene
HGNCHGNC:4456NCBI Gene2820GeneCardsGPD2
Pharmacology
KEGGhsa:2820
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glycerol-3-phosphate dehydrogenase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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