Acid ceramidase

BE0010906ProteinHumansASAH1

Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (PubMed:10610716, PubMed:11451951, PubMed:15655246, PubMed:26898341, PubMed:36752535, PubMed:7744740, PubMed:7852294). It is acted on by 1 drug in DrugBank.

Gene name
ASAH1
UniProtKB entry
Q13510Swiss-Prot
Cellular location
Lysosome
Residues / weight
395 residues · 44,659 Da
Also known as
3.5.1.23 · AC · ACDase · Acid CDase · Acylsphingosine deacylase

Resolves to

Protein
UniProtQ13510UniProt nameASAH1_HUMAN
Gene
HGNCHGNC:735NCBI Gene427GeneCardsASAH1
Pharmacology
KEGGhsa:427
Structure
PDB5U7ZPDB6MHM
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Acid ceramidase, how selective are they, and which programs against it are still in active trials?

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