Bone morphogenetic protein 10

BE0010910ProteinHumansBMP10

Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It is acted on by 1 drug in DrugBank.

Gene name
BMP10
UniProtKB entry
O95393Swiss-Prot
Cellular location
Secreted
Residues / weight
424 residues · 48,047 Da
Also known as
BMP-10

Resolves to

Protein
UniProtO95393UniProt nameBMP10_HUMAN
Gene
HGNCHGNC:20869NCBI Gene27302GeneCardsBMP10
Pharmacology
KEGGhsa:27302
Structure
PDB6SF1PDB6SF3PDB7POI
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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30GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Bone morphogenetic protein 10, and which indications are they being tested in?

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