Immediate early protein IE1

BE0010926ProteinHuman cytomegalovirus (strain Towne)UL123

Plays an important role in transactivating viral early genes as well as activating its own promoter, probably by altering the viral chromatin structure (PubMed:15572445, PubMed:17331553, PubMed:23878222, PubMed:26812545, PubMed:35138119, PubMed:8876134). It is acted on by 1 drug in DrugBank.

Gene name
UL123
UniProtKB entry
P03169Swiss-Prot
Cellular location
Host nucleus
Residues / weight
491 residues · 55,178 Da
Also known as
55 kDa immediate-early protein 1 · IE1 · IE1p72 · IE72

Resolves to

Protein
UniProtP03169UniProt nameVIE1_HCMVT
Structure
PDB4QRUPDB5E5A
Drugs

What you can answer from here — as of November 01, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
4GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
1+ReferenceStructured and connected to the statements they support
Sign in

Which compounds in development act on Immediate early protein IE1, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In