C-type lectin domain family 12 member A

BE0010945ProteinHumansCLEC12A

Myeloid inhibitory C-type lectin receptor that acts as a negative regulator of myeloid cell activation (PubMed:14739280, PubMed:15238421, PubMed:16239426, PubMed:34234773, PubMed:38367667, PubMed:38386511, PubMed:39143217). It is acted on by 3 drugs in DrugBank.

Gene name
CLEC12A
UniProtKB entry
Q5QGZ9Swiss-Prot
Cellular location
Cell membrane
Residues / weight
265 residues · 30,761 Da
Also known as
C-type lectin-like molecule 1 · CLL-1 · CLL1 · DCAL-2 · DCAL2

Resolves to

Protein
UniProtQ5QGZ9UniProt nameCL12A_HUMAN
Gene
HGNCHGNC:31713NCBI Gene160364GeneCardsCLEC12A
Pharmacology
IUPHAR/GtoPdb3081KEGGhsa:160364
Structure
PDB8JAHPDB8W8TPDB8W9J
Drugs

What you can answer from here — as of November 16, 2023

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on C-type lectin domain family 12 member A, and which indications are they being tested in?

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