Gastric inhibitory polypeptide receptor

Details

Name

Gastric inhibitory polypeptide receptor

Kind

protein

Synonyms

• GIP-R
• Glucose-dependent insulinotropic polypeptide receptor

Gene Name

GIPR

UniProtKB Entry

P48546Swiss-Prot

Organism

Humans

NCBI Taxonomy ID

9606

Amino acid sequence

>lcl|BSEQ0054252|Gastric inhibitory polypeptide receptor
MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLA
CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCEN
PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF
MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY
LHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIR
TPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPV
TEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQ
RQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC

Number of residues

466

Molecular Weight

53156.205

Theoretical pI

Not Available

GO Classification

Functions

G protein-coupled peptide receptor activity / gastric inhibitory peptide receptor activity / glucagon family peptide binding / peptide hormone binding / transmembrane signaling receptor activity

Processes

activation of adenylate cyclase activity / adenylate cyclase-activating G protein-coupled receptor signaling pathway / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / cell surface receptor signaling pathway / desensitization of G protein-coupled receptor signaling pathway / endocrine pancreas development / gastric inhibitory peptide signaling pathway / generation of precursor metabolites and energy / positive regulation of cAMP-mediated signaling / positive regulation of cytosolic calcium ion concentration / positive regulation of insulin secretion / regulation of insulin secretion / response to axon injury / response to calcium ion / response to fatty acid / response to glucose / response to nutrient

Components

membrane / plasma membrane

General Function

This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase

Specific Function

G protein-coupled peptide receptor activity

Pfam Domain Function

• 7tm_2 (PF00002)
• HRM (PF02793)

Signal Regions

1-21

Transmembrane Regions

139-161 170-189 218-242 255-278 294-319 342-362 378-398

Cellular Location

Cell membrane

Gene sequence

>lcl|BSEQ0054253|Gastric inhibitory polypeptide receptor (GIPR)
ATGACTACCTCTCCGATCCTGCAGCTGCTGCTGCGGCTCTCACTGTGCGGGCTGCTGCTC
CAGAGGGCGGAGACAGGCTCTAAGGGGCAGACGGCGGGGGAGCTGTACCAGCGCTGGGAA
CGGTACCGCAGGGAGTGCCAGGAGACCTTGGCAGCCGCGGAACCGCCTTCAGGCCTCGCC
TGTAACGGGTCCTTCGATATGTACGTCTGCTGGGACTATGCTGCACCCAATGCCACTGCC
CGTGCGTCCTGCCCCTGGTACCTGCCCTGGCACCACCATGTGGCTGCAGGTTTCGTCCTC
CGCCAGTGTGGCAGTGATGGCCAATGGGGACTTTGGAGAGACCATACACAATGTGAGAAC
CCAGAGAAGAATGAGGCCTTTCTGGACCAAAGGCTCATCTTGGAGCGGTTGCAGGTCATG
TACACTGTCGGCTACTCCCTGTCTCTCGCCACACTGCTGCTAGCCCTGCTCATCTTGAGT
TTGTTCAGGCGGCTACATTGCACTAGAAACTATATCCACATCAACCTGTTCACGTCTTTC
ATGCTGCGAGCTGCGGCCATTCTCAGCCGAGACCGTCTGCTACCTCGACCTGGCCCCTAC
CTTGGGGACCAGGCCCTTGCGCTGTGGAACCAGGCCCTCGCTGCCTGCCGCACGGCCCAG
ATCGTGACCCAGTACTGCGTGGGTGCCAACTACACGTGGCTGCTGGTGGAGGGCGTCTAC
CTGCACAGTCTCCTGGTGCTCGTGGGAGGCTCCGAGGAGGGCCACTTCCGCTACTACCTG
CTCCTCGGCTGGGGGGCCCCCGCGCTTTTCGTCATTCCCTGGGTGATCGTCAGGTACCTG
TACGAGAACACGCAGTGCTGGGAGCGCAACGAAGTCAAGGCCATTTGGTGGATTATACGG
ACCCCCATCCTCATGACCATCTTGATTAATTTCCTCATTTTTATCCGCATTCTTGGCATT
CTCCTGTCCAAGCTGAGGACACGGCAAATGCGCTGCCGGGATTACCGGCTGAGGCTGGCT
CGCTCCACGCTGACGCTGGTGCCCCTGCTGGGTGTCCACGAGGTGGTGTTTGCTCCCGTG
ACAGAGGAACAGGCCCGGGGCGCCCTGCGCTTCGCCAAGCTCGGCTTTGAGATCTTCCTC
AGCTCCTTCCAGGGCTTCCTGGTCAGCGTCCTCTACTGCTTCATCAACAAGGAGGTGCAG
TCGGAGATCCGCCGTGGCTGGCACCACTGCCGCCTGCGCCGCAGCCTGGGCGAGGAGCAA
CGCCAGCTCCCGGAGCGCGCCTTCCGGGCCCTGCCCTCCGGCTCCGGCCCGGGCGAGGTC
CCCACCAGCCGCGGCTTGTCCTCGGGGACCCTCCCAGGGCCTGGGAATGAGGCCAGCCGG
GAGTTGGAAAGTTACTGCTAG

Chromosome Location

19

Locus

19q13.32

External Identifiers

Resource	Link
UniProtKB ID	P48546
UniProtKB Entry Name	GIPR_HUMAN
GeneCard ID	GIPR
HGNC ID	HGNC:4271
PDB ID(s)	2QKH, 4HJ0, 6DKJ, 7DTY, 7FIN, 7FIY, 7RA3, 7RBT, 7VAB, 8ITL, 8ITM, 8WA3
KEGG ID	hsa:2696
IUPHAR/Guide To Pharmacology ID	248
NCBI Gene ID	2696

General References

Not Available

Associated Data

Drug Relations

Drug	Drug group	Pharmacological action?	Type	Actions	Details
Tirzepatide	approved, investigational	yes	target	agonist	Details