Interleukin-31 receptor subunit alpha
Details
- Name
- Interleukin-31 receptor subunit alpha
- Kind
- protein
- Synonyms
- CRL3
- Cytokine receptor-like 3
- GLM-R
- Gp130-like monocyte receptor
- Gp130-like receptor
- GPL
- hGLM-R
- IL-31 receptor subunit alpha
- IL-31R subunit alpha
- IL-31R-alpha
- IL-31RA
- ZcytoR17
- Gene Name
- IL31RA
- UniProtKB Entry
- Q8NI17Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0054254|Interleukin-31 receptor subunit alpha MMWTWALWMLPSLCKFSLAALPAKPENISCVYYYRKNLTCTWSPGKETSYTQYTVKRTYA FGEKHDNCTTNSSTSENRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIA KTEPPKIFRVKPVLGIKRMIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRK DKNQTYNLTGLQPFTEYVIALRCAVKESKFWSDWSQEKMGMTEEEAPCGLELWRVLKPAE ADGRRPVRLLWKKARGAPVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWV SMISYNSLGKSPVATLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNTWMIEWF PDVDSEPTTLSWESVSQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGV PSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYG LESLKRKTSYIVQVMASTSAGGTNGTSINFKTLSFSVFEIILITSLIGGGLLILIILTVA YGLKKPNKLTHLCWPTVPNPAESSIATWHGDDFKDKLNLKESDDSVNTEDRILKPCSTPS DKLVIDKLVVNFGNVLQEIFTDEARTGQENNLGGEKNGYVTCPFRPDCPLGKSFEELPVS PEIPPRKSQYLRSRMPEGTRPEAKEQLLFSGQSLVPDHLCEEGAPNPYLKNSVTAREFLV SEKLPEHTKGEV
- Number of residues
- 732
- Molecular Weight
- 82953.195
- Theoretical pI
- Not Available
- GO Classification
- Functionscytokine binding / cytokine receptor activity / protein kinase binding / transcription coactivator activityProcessesacute inflammatory response to antigenic stimulus / cell surface receptor protein tyrosine kinase signaling pathway / cell surface receptor signaling pathway via JAK-STAT / cytokine-mediated signaling pathway / defense response / defense response to other organism / glandular epithelial cell differentiation / homeostatic process / macrophage differentiation / MAPK cascade / monocyte differentiation / negative regulation of apoptotic process / negative regulation of macrophage activation / positive regulation of cell population proliferation / positive regulation of DNA-templated transcription / positive regulation of tyrosine phosphorylation of STAT proteinComponentsaxon / external side of plasma membrane / membrane / plasma membrane / presynaptic membrane / receptor complex
- General Function
- Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 (PubMed:11877449, PubMed:14504285, PubMed:15194700, PubMed:15627637). May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity)
- Specific Function
- Cytokine binding
- Pfam Domain Function
- Signal Regions
- 1-19
- Transmembrane Regions
- 520-540
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0054255|Interleukin-31 receptor subunit alpha (IL31RA) ATGAAGCTCTCTCCCCAGCCTTCATGTGTTAACCTGGGGATGATGTGGACCTGGGCACTG TGGATGCTCCCCTCACTCTGCAAATTCAGCCTGGCAGCTCTGCCAGCTAAGCCTGAGAAC ATTTCCTGTGTCTACTACTATAGGAAAAATTTAACCTGCACTTGGAGTCCAGGAAAGGAA ACCAGTTATACCCAGTACACAGTTAAGAGAACTTACGCTTTTGGAGAAAAACATGATAAT TGTACAACCAATAGTTCTACAAGTGAAAATCGTGCTTCGTGCTCTTTTTTCCTTCCAAGA ATAACGATCCCAGATAATTATACCATTGAGGTGGAAGCTGAAAATGGAGATGGTGTAATT AAATCTCATATGACATACTGGAGATTAGAGAACATAGCGAAAACTGAACCACCTAAGATT TTCCGTGTGAAACCAGTTTTGGGCATCAAACGAATGATTCAAATTGAATGGATAAAGCCT GAGTTGGCGCCTGTTTCATCTGATTTAAAATACACACTTCGATTCAGGACAGTCAACAGT ACCAGCTGGATGGAAGTCAACTTCGCTAAGAACCGTAAGGATAAAAACCAAACGTACAAC CTCACGGGGCTGCAGCCTTTTACAGAATATGTCATAGCTCTGCGATGTGCGGTCAAGGAG TCAAAGTTCTGGAGTGACTGGAGCCAAGAAAAAATGGGAATGACTGAGGAAGAAGCTCCA TGTGGCCTGGAACTGTGGAGAGTCCTGAAACCAGCTGAGGCGGATGGAAGAAGGCCAGTG CGGTTGTTATGGAAGAAGGCAAGAGGAGCCCCAGTCCTAGAGAAAACACTTGGCTACAAC ATATGGTACTATCCAGAAAGCAACACTAACCTCACAGAAACAATGAACACTACTAACCAG CAGCTTGAACTGCATCTGGGAGGCGAGAGCTTTTGGGTGTCTATGATTTCTTATAATTCT CTTGGGAAGTCTCCAGTGGCCACCCTGAGGATTCCAGCTATTCAAGAAAAATCATTTCAG TGCATTGAGGTCATGCAGGCCTGCGTTGCTGAGGACCAGCTAGTGGTGAAGTGGCAAAGC TCTGCTCTAGACGTGAACACTTGGATGATTGAATGGTTTCCGGATGTGGACTCAGAGCCC ACCACCCTTTCCTGGGAATCTGTGTCTCAGGCCACGAACTGGACGATCCAGCAAGATAAA TTAAAACCTTTCTGGTGCTATAACATCTCTGTGTATCCAATGTTGCATGACAAAGTTGGC GAGCCATATTCCATCCAGGCTTATGCCAAAGAAGGCGTTCCATCAGAAGGTCCTGAGACC AAGGTGGAGAACATTGGCGTGAAGACGGTCACGATCACATGGAAAGAGATTCCCAAGAGT GAGAGAAAGGGTATCATCTGCAACTACACCATCTTTTACCAAGCTGAAGGTGGAAAAGGA TTCTCCAAGACAGTCAATTCCAGCATCTTGCAGTACGGCCTGGAGTCCCTGAAACGAAAG ACCTCTTACATTGTTCAGGTCATGGCCAGCACCAGTGCTGGGGGAACCAACGGGACCAGC ATAAATTTCAAGACATTGTCATTCAGTGTCTTTGAGATTATCCTCATAACTTCTCTGATT GGTGGAGGCCTTCTTATTCTCATTATCCTGACAGTGGCATATGGTCTCAAAAAACCCAAC AAATTGACTCATCTGTGTTGGCCCACCGTTCCCAACCCTGCTGAAAGTAGTATAGCCACA TGGCATGGAGATGATTTCAAGGATAAGCTAAACCTGAAGGAGTCTGATGACTCTGTGAAC ACAGAAGACAGGATCTTAAAACCATGTTCCACCCCCAGTGACAAGTTGGTGATTGACAAG TTGGTGGTGAACTTTGGGAATGTTCTGCAAGAAATTTTCACAGATGAAGCCAGAACGGGT CAGGAAAACAATTTAGGAGGGGAAAAGAATGGGTATGTGACCTGCCCCTTCAGGCCTGAT TGTCCCCTGGGGAAAAGTTTTGAGGAGCTCCCAGTTTCACCTGAGATTCCGCCCAGAAAA TCCCAATACCTACGTTCGAGGATGCCAGAGGGGACCCGCCCAGAAGCCAAAGAGCAGCTT CTCTTTTCTGGTCAAAGTTTAGTACCAGATCATCTGTGTGAGGAAGGAGCCCCAAATCCA TATTTGAAAAATTCAGTGACAGCCAGGGAATTTCTTGTGTCTGAAAAACTTCCAGAGCAC ACCAAGGGAGAAGTCTAA
- Chromosome Location
- 5
- Locus
- 5q11.2
- External Identifiers
Resource Link UniProtKB ID Q8NI17 UniProtKB Entry Name IL31R_HUMAN GeneCard ID IL31RA HGNC ID HGNC:18969 KEGG ID hsa:133396 IUPHAR/Guide To Pharmacology ID 1710 NCBI Gene ID 133396 - General References
- Not Available
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Nemolizumab approved, investigational yes target antagonistantibody Details