Interleukin-31 receptor subunit alpha

BE0011013ProteinHumansIL31RA

Functions as a membrane-bound signal-transducing subunit of the IL31 receptor complex (heterodimer composed of OSMR and IL31RA) which binds IL31 (PubMed:15184896, PubMed:15194700, PubMed:15627637). It is acted on by 1 drug in DrugBank.

Gene name
IL31RA
UniProtKB entry
Q8NI17Swiss-Prot
Cellular location
Cell membrane
Residues / weight
732 residues · 82,953 Da
Also known as
CRL3 · Cytokine receptor-like 3 · GLM-R · Gp130-like monocyte receptor · Gp130-like receptor

Resolves to

Protein
UniProtQ8NI17UniProt nameIL31R_HUMAN
Gene
HGNCHGNC:18969NCBI Gene133396GeneCardsIL31RA
Pharmacology
IUPHAR/GtoPdb1710KEGGhsa:133396
Structure
PDB9EZA
Drugs

What you can answer from here — as of August 01, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
22GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
4+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Interleukin-31 receptor subunit alpha, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In