Torsin-1A

BE0011037ProteinHumansTOR1A

Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. It is acted on by 1 drug in DrugBank.

Gene name
TOR1A
UniProtKB entry
O14656Swiss-Prot
Cellular location
Endoplasmic reticulum lumen
Residues / weight
332 residues · 37,808 Da
Also known as
DQ2 · Dystonia 1 protein · DYT1 · TA · TORA

Resolves to

Protein
UniProtO14656UniProt nameTOR1A_HUMAN
Gene
HGNCHGNC:3098NCBI Gene1861GeneCardsTOR1A
Pharmacology
KEGGhsa:1861
Structure
PDB5J1SPDB5J1TPDB6OIF
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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36GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Torsin-1A, how selective are they, and which programs against it are still in active trials?

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