Tripeptidyl-peptidase 1

BE0011158ProteinHumansTPP1

Lysosomal serine protease with tripeptidyl-peptidase I activity (PubMed:11054422, PubMed:19038966, PubMed:19038967). It is acted on by 1 drug in DrugBank.

Gene name
TPP1
UniProtKB entry
O14773Swiss-Prot
Cellular location
Lysosome
Residues / weight
563 residues · 61,247 Da
Also known as
3.4.14.9 · Cell growth-inhibiting gene 1 protein · CLN2 · LPIC · Lysosomal pepstatin-insensitive protease

Resolves to

Protein
UniProtO14773UniProt nameTPP1_HUMAN
Gene
HGNCHGNC:2073NCBI Gene1200GeneCardsTPP1
Pharmacology
KEGGhsa:1200
Structure
PDB3EDYPDB3EE6
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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26GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Tripeptidyl-peptidase 1, how selective are they, and which programs against it are still in active trials?

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