Transcription elongation factor SPT5

BE0011188ProteinHumansSUPT5H

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10421630, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:12653964, PubMed:12718890, PubMed:15136722, PubMed:15380072, PubMed:9450929, PubMed:9857195). It is acted on by 1 drug in DrugBank.

Gene name
SUPT5H
UniProtKB entry
O00267Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,087 residues · 120,999 Da
Also known as
DRB sensitivity-inducing factor 160 kDa subunit · DRB sensitivity-inducing factor large subunit · DSIF large subunit · DSIF p160 · hSPT5

Resolves to

Protein
UniProtO00267UniProt nameSPT5H_HUMAN
Gene
HGNCHGNC:11469NCBI Gene6829GeneCardsSUPT5H
Pharmacology
KEGGhsa:6829
Structure
PDB2DO3PDB2E6ZPDB2E70
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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10Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Transcription elongation factor SPT5, and which indications are they being tested in?

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