DNA-directed RNA polymerase III subunit RPC1

BE0011220ProteinHumansPOLR3A

Catalytic core component of RNA polymerase III (Pol III), a DNA-dependent RNA polymerase which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. It is acted on by 1 drug in DrugBank.

Gene name
POLR3A
UniProtKB entry
O14802Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,390 residues · 155,640 Da
Also known as
2.7.7.6 · DNA-directed RNA polymerase III largest subunit · DNA-directed RNA polymerase III subunit A · RNA polymerase III 155 kDa subunit · RNA polymerase III subunit C1

Resolves to

Protein
UniProtO14802UniProt nameRPC1_HUMAN
Gene
HGNCHGNC:30074NCBI Gene11128GeneCardsPOLR3A
Pharmacology
KEGGhsa:11128
Structure
PDB7A6HPDB7AE1PDB7AE3
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on DNA-directed RNA polymerase III subunit RPC1, and which indications are they being tested in?

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