Interferon-inducible protein AIM2

BE0011287ProteinHumansAIM2

Sensor component of the AIM2 inflammasome, which mediates inflammasome activation in response to the presence of double-stranded DNA (dsDNA) in the cytosol, leading to subsequent pyroptosis (PubMed:17726700, PubMed:19158675, PubMed:19158676, PubMed:19158679, PubMed:20566831, PubMed:23530044, PubMed:26197926, PubMed:26583071, PubMed:29440442,... It is acted on by 1 drug in DrugBank.

Gene name
AIM2
UniProtKB entry
O14862Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
343 residues · 38,953 Da
Also known as
Absent in melanoma 2

Resolves to

Protein
UniProtO14862UniProt nameAIM2_HUMAN
Gene
HGNCHGNC:357NCBI Gene9447GeneCardsAIM2
Pharmacology
KEGGhsa:9447
Structure
PDB3RN2PDB3RN5PDB3VD8
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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32GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Interferon-inducible protein AIM2, and which indications are they being tested in?

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