Dynamin-1-like protein

BE0011347ProteinHumansDNM1L

Functions in mitochondrial and peroxisomal division (PubMed:11514614, PubMed:12499366, PubMed:17301055, PubMed:17460227, PubMed:17553808, PubMed:18695047, PubMed:18838687, PubMed:19342591, PubMed:19411255, PubMed:19638400, PubMed:23283981, PubMed:23530241, PubMed:23921378, PubMed:26992161, PubMed:27145208, PubMed:27145933, PubMed:27301544, PubMed:27328748, PubMed:29478834, PubMed:32439975, PubMed:32484300, PubMed:9570752, PubMed:9786947). It is acted on by 2 drugs in DrugBank.

Gene name
DNM1L
UniProtKB entry
O00429Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
736 residues · 81,876 Da
Also known as
3.6.5.5 · DLP1 · Dnm1p/Vps1p-like protein · DRP1 · DVLP

Resolves to

Protein
UniProtO00429UniProt nameDNM1L_HUMAN
Gene
HGNCHGNC:2973NCBI Gene10059GeneCardsDNM1L
Pharmacology
KEGGhsa:10059
Structure
PDB3W6NPDB3W6OPDB3W6P
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Dynamin-1-like protein, and which indications are they being tested in?

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