Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

BE0011403ProteinHumansENPP3

Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (PubMed:29717535, PubMed:9344668). It is acted on by 1 drug in DrugBank.

Gene name
ENPP3
UniProtKB entry
O14638Swiss-Prot
Cellular location
Cell membrane
Residues / weight
875 residues · 100,124 Da
Also known as
Alkaline phosphodiesterase I · Dinucleoside polyphosphatase · E-NPP 3 · NPP3 · NPPase

Resolves to

Protein
UniProtO14638UniProt nameENPP3_HUMAN
Gene
HGNCHGNC:3358NCBI Gene5169GeneCardsENPP3
Pharmacology
KEGGhsa:5169
Structure
PDB6C01PDB6C02PDB9NIR
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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29GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Ectonucleotide pyrophosphatase/phosphodiesterase family member 3, and which indications are they being tested in?

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