Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3

BE0011438ProteinHumansST8SIA3

Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an acceptor, such as N-linked oligosaccharides of glycoproteins and glycolipids through alpha-2,8-linkages (PubMed:10766765,... It is acted on by 1 drug in DrugBank.

Gene name
ST8SIA3
UniProtKB entry
O43173Swiss-Prot
Cellular location
Golgi apparatus membrane
Residues / weight
380 residues · 43,970 Da
Also known as
2.4.3.- · Alpha-2,8-sialyltransferase 8C · Alpha-2,8-sialyltransferase III · Ganglioside GD3 synthase ST8SIA3 · hST8Sia III

Resolves to

Protein
UniProtO43173UniProt nameSIA8C_HUMAN
Gene
HGNCHGNC:14269NCBI Gene51046GeneCardsST8SIA3
Pharmacology
KEGGhsa:51046
Structure
PDB5BO6PDB5BO7PDB5BO8
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3, and which indications are they being tested in?

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