Tumor necrosis factor ligand superfamily member 14

BE0011440ProteinHumansTNFSF14

Cytokine that binds to TNFRSF3/LTB and TNFRSF14/HVEM and plays major roles in immune system regulation (PubMed:10754304, PubMed:9462508). It is acted on by 2 drugs in DrugBank.

Gene name
TNFSF14
UniProtKB entry
O43557Swiss-Prot
Cellular location
Cell membrane
Residues / weight
240 residues · 26,350 Da
Also known as
Herpes virus entry mediator ligand · Herpesvirus entry mediator ligand · HVEM-L · HVEML · LIGHT

Resolves to

Protein
UniProtO43557UniProt nameTNF14_HUMAN
Gene
HGNCHGNC:11930NCBI Gene8740GeneCardsTNFSF14
Pharmacology
KEGGhsa:8740
Structure
PDB4EN0PDB4J6GPDB4KG8
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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26GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Tumor necrosis factor ligand superfamily member 14, and which indications are they being tested in?

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