SMAD family member 7

BE0011560ProteinHumansSMAD7

Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access (PubMed:21791611). It is acted on by 1 drug in DrugBank.

Gene name
SMAD7
UniProtKB entry
O15105Swiss-Prot
Cellular location
Nucleus
Residues / weight
426 residues · 46,425 Da
Also known as
hSMAD7 · MAD homolog 7 · MAD homolog 8 · MADH7 · MADH8

Resolves to

Protein
UniProtO15105UniProt nameSMAD7_HUMAN
Gene
HGNCHGNC:6773NCBI Gene4092GeneCardsSMAD7
Pharmacology
KEGGhsa:4092
Structure
PDB2DJYPDB2KXQPDB2LTV
Drugs

What you can answer from here — as of June 05, 2026

1DrugApproved to experimental, with action, bond type and pharmacological action
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51GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on SMAD family member 7, and which indications are they being tested in?

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