1-acyl-sn-glycerol-3-phosphate acyltransferase beta

BE0011578ProteinHumansAGPAT2

Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. It is acted on by 1 drug in DrugBank.

Gene name
AGPAT2
UniProtKB entry
O15120Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
278 residues · 30,914 Da
Also known as
1-acylglycerol-3-phosphate O-acyltransferase 2 · 1-AGP acyltransferase 2 · 1-AGPAT 2 · 2.3.1.51 · LPAAT-beta

Resolves to

Protein
UniProtO15120UniProt namePLCB_HUMAN
Gene
HGNCHGNC:325NCBI Gene10555GeneCardsAGPAT2
Pharmacology
KEGGhsa:10555
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 1-acyl-sn-glycerol-3-phosphate acyltransferase beta, and which indications are they being tested in?

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