Phospholipid-transporting ATPase VA

BE0011629ProteinHumansATP10A

Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane (PubMed:25947375, PubMed:29599178, PubMed:30530492). It is acted on by 1 drug in DrugBank.

Gene name
ATP10A
UniProtKB entry
O60312Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,499 residues · 167,687 Da
Also known as
7.6.2.1 · Aminophospholipid translocase VA · ATP10C · ATPase class V type 10A · ATPVA

Resolves to

Protein
UniProtO60312UniProt nameAT10A_HUMAN
Gene
HGNCHGNC:13542NCBI Gene57194GeneCardsATP10A
Pharmacology
KEGGhsa:57194
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Phospholipid-transporting ATPase VA, and which indications are they being tested in?

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