E3 ubiquitin ligase TRAF3IP2

BE0011632ProteinHumansTRAF3IP2

E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). It is acted on by 1 drug in DrugBank.

Gene name
TRAF3IP2
UniProtKB entry
O43734Swiss-Prot
Residues / weight
574 residues · 64,666 Da
Also known as
2.3.2.27 · ACT1 · Adapter protein CIKS · C6orf2 · C6orf4

Resolves to

Protein
UniProtO43734UniProt nameCIKS_HUMAN
Gene
HGNCHGNC:1343NCBI Gene10758GeneCardsTRAF3IP2
Pharmacology
KEGGhsa:10758
Structure
PDB9OT1
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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41GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on E3 ubiquitin ligase TRAF3IP2, and which indications are they being tested in?

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