Insulin-induced gene 1 protein

BE0011639ProteinHumansINSIG1

Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12202038, PubMed:12535518, PubMed:16168377, PubMed:16399501, PubMed:16606821, PubMed:32322062). It is acted on by 1 drug in DrugBank.

Gene name
INSIG1
UniProtKB entry
O15503Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
277 residues · 29,986 Da
Also known as
INSIG-1

Resolves to

Protein
UniProtO15503UniProt nameINSI1_HUMAN
Gene
HGNCHGNC:6083NCBI Gene3638GeneCardsINSIG1
Pharmacology
KEGGhsa:3638
Structure
PDB4J81
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Insulin-induced gene 1 protein, and which indications are they being tested in?

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