Kynurenine 3-monooxygenase

BE0011714ProteinHumansKMO

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702, PubMed:29429898). It is acted on by 1 drug in DrugBank.

Gene name
KMO
UniProtKB entry
O15229Swiss-Prot
Cellular location
Mitochondrion outer membrane
Residues / weight
486 residues · 55,809 Da
Also known as
1.14.13.9 · Kynurenine 3-hydroxylase

Resolves to

Protein
UniProtO15229UniProt nameKMO_HUMAN
Gene
HGNCHGNC:6381NCBI Gene8564GeneCardsKMO
Pharmacology
IUPHAR/GtoPdb2886KEGGhsa:8564
Structure
PDB5X68
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Kynurenine 3-monooxygenase, and which indications are they being tested in?

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