Tumor necrosis factor ligand superfamily member 12

BE0011752ProteinHumansTNFSF12

Binds to FN14 and possibly also to TNRFSF12/APO3. It is acted on by 1 drug in DrugBank.

Gene name
TNFSF12
UniProtKB entry
O43508Swiss-Prot
Cellular location
Cell membrane
Residues / weight
249 residues · 27,216 Da
Also known as
APO3 ligand · APO3L · DR3LG · TNF-related weak inducer of apoptosis · TWEAK

Resolves to

Protein
UniProtO43508UniProt nameTNF12_HUMAN
Gene
HGNCHGNC:11927NCBI Gene8742GeneCardsTNFSF12
Pharmacology
KEGGhsa:8742
Structure
PDB4HT1
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Tumor necrosis factor ligand superfamily member 12, and which indications are they being tested in?

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