Phospholipid-transporting ATPase IC

BE0011765ProteinHumansATP8B1

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane (PubMed:17948906,... It is acted on by 1 drug in DrugBank.

Gene name
ATP8B1
UniProtKB entry
O43520Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,251 residues · 143,694 Da
Also known as
7.6.2.1 · ATPase class I type 8B member 1 · ATPIC · Familial intrahepatic cholestasis type 1 · FIC1

Resolves to

Protein
UniProtO43520UniProt nameAT8B1_HUMAN
Gene
HGNCHGNC:3706NCBI Gene5205GeneCardsATP8B1
Pharmacology
KEGGhsa:5205
Structure
PDB7PY4PDB7VGHPDB7VGI
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Phospholipid-transporting ATPase IC, and which indications are they being tested in?

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