Gremlin-1

BE0011799ProteinHumansGREM1

Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. It is acted on by 1 drug in DrugBank.

Gene name
GREM1
UniProtKB entry
O60565Swiss-Prot
Cellular location
Secreted
Residues / weight
184 residues · 20,697 Da
Also known as
Cell proliferation-inducing gene 2 protein · CKTSF1B1 · Cysteine knot superfamily 1, BMP antagonist 1 · DAN domain family member 2 · DAND2

Resolves to

Protein
UniProtO60565UniProt nameGREM1_HUMAN
Gene
HGNCHGNC:2001NCBI Gene26585GeneCardsGREM1
Pharmacology
KEGGhsa:26585
Structure
PDB5AEJPDB8B7H
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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42GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Gremlin-1, and which indications are they being tested in?

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