GDNF family receptor alpha-3

BE0011826ProteinHumansGFRA3

Receptor for artemin (ARTN), a growth factor that supports the survival of sensory and sympathetic peripheral neurons (PubMed:31535977, PubMed:9883723). It is acted on by 1 drug in DrugBank.

Gene name
GFRA3
UniProtKB entry
O60609Swiss-Prot
Cellular location
Cell membrane
Residues / weight
400 residues · 44,510 Da
Also known as
GDNF receptor alpha-3 · GDNFR-alpha-3 · GFR-alpha-3

Resolves to

Protein
UniProtO60609UniProt nameGFRA3_HUMAN
Gene
HGNCHGNC:4245NCBI Gene2676GeneCardsGFRA3
Pharmacology
KEGGhsa:2676
Structure
PDB2GH0PDB6Q2S
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on GDNF family receptor alpha-3, and which indications are they being tested in?

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