Protein-S-isoprenylcysteine O-methyltransferase

BE0011941ProteinHumansICMT

Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues. It is acted on by 1 drug in DrugBank.

Gene name
ICMT
UniProtKB entry
O60725Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
284 residues · 31,938 Da
Also known as
2.1.1.100 · Isoprenylcysteine carboxylmethyltransferase · PCCMT · PPMT · Prenylated protein carboxyl methyltransferase

Resolves to

Protein
UniProtO60725UniProt nameICMT_HUMAN
Gene
HGNCHGNC:5350NCBI Gene23463GeneCardsICMT
Pharmacology
KEGGhsa:23463
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Protein-S-isoprenylcysteine O-methyltransferase, and which indications are they being tested in?

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