Lysine-specific demethylase 4A

BE0011989ProteinHumansKDM4A

Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:16603238, PubMed:26741168, PubMed:21768309). It is acted on by 1 drug in DrugBank.

Gene name
KDM4A
UniProtKB entry
O75164Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,064 residues · 120,661 Da
Also known as
[histone H3]-trimethyl-L-lysine(36) demethylase 4A · [histone H3]-trimethyl-L-lysine(9) demethylase 4A · 1.14.11.66 · 1.14.11.69 · JHDM3A

Resolves to

Protein
UniProtO75164UniProt nameKDM4A_HUMAN
Gene
HGNCHGNC:22978NCBI Gene9682GeneCardsKDM4A
Pharmacology
IUPHAR/GtoPdb2675KEGGhsa:9682
Structure
PDB2GF7PDB2GFAPDB2GP3
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Lysine-specific demethylase 4A, and which indications are they being tested in?

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