H/ACA ribonucleoprotein complex subunit DKC1

BE0012026ProteinHumansDKC1

Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674, PubMed:32554502). It is acted on by 1 drug in DrugBank.

Gene name
DKC1
UniProtKB entry
O60832Swiss-Prot
Cellular location
Nucleus, nucleolus
Residues / weight
514 residues · 57,674 Da
Also known as
5.4.99.- · CBF5 homolog · Dyskerin · NOLA4 · Nopp140-associated protein of 57 kDa

Resolves to

Protein
UniProtO60832UniProt nameDKC1_HUMAN
Gene
HGNCHGNC:2890NCBI Gene1736GeneCardsDKC1
Pharmacology
KEGGhsa:1736
Structure
PDB7BGBPDB7TRCPDB7V9A
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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29GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on H/ACA ribonucleoprotein complex subunit DKC1, and which indications are they being tested in?

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