Low-density lipoprotein receptor-related protein 6

BE0012061ProteinHumansLRP6

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes (PubMed:11357136, PubMed:11448771, PubMed:15778503, PubMed:16341017, PubMed:16513652, PubMed:17326769, PubMed:17400545, PubMed:19107203, PubMed:19293931, PubMed:19801552, PubMed:28341812, PubMed:34896607). It is acted on by 1 drug in DrugBank.

Gene name
LRP6
UniProtKB entry
O75581Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,613 residues · 180,428 Da
Also known as
LRP-6

Resolves to

Protein
UniProtO75581UniProt nameLRP6_HUMAN
Gene
HGNCHGNC:6698NCBI Gene4040GeneCardsLRP6
Pharmacology
KEGGhsa:4040
Structure
PDB3S2KPDB3S8VPDB3S8Z
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
1GO termFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
1+ReferenceStructured and connected to the statements they support
Sign in

Which compounds in development act on Low-density lipoprotein receptor-related protein 6, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In