Arachidonate 12-lipoxygenase, 12R-type

BE0012120ProteinHumansALOX12B

Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:21558561, PubMed:9618483, PubMed:9837935). It is acted on by 1 drug in DrugBank.

Gene name
ALOX12B
UniProtKB entry
O75342Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
701 residues · 80,355 Da
Also known as
1.13.11.- · 12R-lipoxygenase · 12R-LOX · Epidermis-type lipoxygenase 12

Resolves to

Protein
UniProtO75342UniProt nameLX12B_HUMAN
Gene
HGNCHGNC:430NCBI Gene242GeneCardsALOX12B
Pharmacology
KEGGhsa:242
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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20GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Arachidonate 12-lipoxygenase, 12R-type, and which indications are they being tested in?

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