Histone-lysine N-methyltransferase NSD2

BE0012398ProteinHumansNSD2

Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2) (PubMed:19808676, PubMed:22099308, PubMed:27571355, PubMed:29728617, PubMed:33941880). It is acted on by 2 drugs in DrugBank.

Gene name
NSD2
UniProtKB entry
O96028Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,365 residues · 152,257 Da
Also known as
2.1.1.357 · KIAA1090 · MMSET · Multiple myeloma SET domain-containing protein · Nuclear SET domain-containing protein 2

Resolves to

Protein
UniProtO96028UniProt nameNSD2_HUMAN
Gene
HGNCHGNC:12766NCBI Gene7468GeneCardsNSD2
Pharmacology
IUPHAR/GtoPdb3220KEGGhsa:7468
Structure
PDB29HGPDB29HHPDB29HI
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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9Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Histone-lysine N-methyltransferase NSD2, and which indications are they being tested in?

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