Antiviral innate immune response receptor RIG-I

BE0012418ProteinHumansRIGI

Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines (PubMed:15208624, PubMed:15708988, PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:17190814, PubMed:18636086, PubMed:19122199, PubMed:19211564,... It is acted on by 2 drugs in DrugBank.

Gene name
RIGI
UniProtKB entry
O95786Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
925 residues · 106,599 Da
Also known as
ATP-dependent RNA helicase DDX58 · DDX58 · DEAD box protein 58 · Retinoic acid-inducible gene 1 protein · Retinoic acid-inducible gene I protein

Resolves to

Protein
UniProtO95786UniProt nameRIGI_HUMAN
Gene
HGNCHGNC:19102NCBI Gene23586GeneCardsRIGI
Pharmacology
KEGGhsa:23586
Structure
PDB2LWDPDB2LWEPDB2QFB
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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41GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Antiviral innate immune response receptor RIG-I, and which indications are they being tested in?

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