Phosphatidylcholine-sterol acyltransferase

BE0012488ProteinHumansLCAT

Central enzyme in the extracellular metabolism of plasma lipoproteins. It is acted on by 6 drugs in DrugBank.

Gene name
LCAT
UniProtKB entry
P04180Swiss-Prot
Cellular location
Secreted
Residues / weight
440 residues · 49,578 Da
Also known as
1-alkyl-2-acetylglycerophosphocholine esterase · 2.3.1.43 · Lecithin-cholesterol acyltransferase · PAF acetylhydrolase · Phospholipid-cholesterol acyltransferase

Resolves to

Protein
UniProtP04180UniProt nameLCAT_HUMAN
Gene
HGNCHGNC:6522NCBI Gene3931GeneCardsLCAT
Pharmacology
KEGGhsa:3931
Structure
PDB4X96PDB4XWGPDB4XX1
Drugs

What you can answer from here — as of September 03, 2024

6DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phosphatidylcholine-sterol acyltransferase, how selective are they, and which programs against it are still in active trials?

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