Pepsin A-3

BE0012527ProteinHumansPGA3

Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. It is acted on by 2 drugs in DrugBank.

Gene name
PGA3
UniProtKB entry
P0DJD8Swiss-Prot
Cellular location
Secreted
Residues / weight
388 residues · 41,976 Da
Also known as
3.4.23.1 · Pepsinogen-3

Resolves to

Protein
UniProtP0DJD8UniProt namePEPA3_HUMAN
Gene
HGNCHGNC:8885NCBI Gene643834GeneCardsPGA3
Pharmacology
KEGGhsa:643834
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Pepsin A-3, how selective are they, and which programs against it are still in active trials?

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