Pulmonary surfactant-associated protein B

BE0012543ProteinHumansSFTPB

Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. It is acted on by 2 drugs in DrugBank.

Gene name
SFTPB
UniProtKB entry
P07988Swiss-Prot
Cellular location
Secreted, extracellular space, surface film
Residues / weight
381 residues · 42,117 Da
Also known as
18 kDa pulmonary-surfactant protein · 6 kDa protein · Pulmonary surfactant-associated proteolipid SPL(Phe) · SFTP3 · SP-B

Resolves to

Protein
UniProtP07988UniProt namePSPB_HUMAN
Gene
HGNCHGNC:10801NCBI Gene6439GeneCardsSFTPB
Pharmacology
KEGGhsa:6439
Structure
PDB1DFWPDB1KMRPDB1RG3
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Pulmonary surfactant-associated protein B, how selective are they, and which programs against it are still in active trials?

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